One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones

One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones

Herein, a direct strategy to synthesize 3-(2-hydroxybenzoyl)-1-aza-anthraquinones with excellent efficiency, mild conditions, and benign functional group compatibility was reported. A variety of 3-formylchromone compounds were employed as compatible substrates and this protocol gave the 3-(2-hydroxy...

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Main Authors: Jiaqi Yuan, Qian He, Shanshan Song, Xiaofei Zhang, Zehong Miao, Chunhao Yang
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
3-(2-hydroxybenzoyl)-1-aza-anthraquinones
chromones
anti-proliferation agent
Online Access:https://www.mdpi.com/1420-3049/24/16/3017
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spelling doaj-5706de60694d47b7b22802418cde535c2020-11-25T00:28:02ZengMDPI AGMolecules1420-30492019-08-012416301710.3390/molecules24163017molecules24163017One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinonesJiaqi Yuan0Qian He1Shanshan Song2Xiaofei Zhang3Zehong Miao4Chunhao Yang5State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, ChinaHerein, a direct strategy to synthesize 3-(2-hydroxybenzoyl)-1-aza-anthraquinones with excellent efficiency, mild conditions, and benign functional group compatibility was reported. A variety of 3-formylchromone compounds were employed as compatible substrates and this protocol gave the 3-(2-hydroxybenzoyl)-1-aza-anthraquinone derivatives in good to excellent yields without inert gas and expensive transition metal catalysts. Some compounds displayed good anti-proliferative activities.https://www.mdpi.com/1420-3049/24/16/30173-(2-hydroxybenzoyl)-1-aza-anthraquinoneschromonesanti-proliferation agent
collection DOAJ
language English
format Article
sources DOAJ
author Jiaqi Yuan
Qian He
Shanshan Song
Xiaofei Zhang
Zehong Miao
Chunhao Yang
spellingShingle Jiaqi Yuan
Qian He
Shanshan Song
Xiaofei Zhang
Zehong Miao
Chunhao Yang
One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
Molecules
3-(2-hydroxybenzoyl)-1-aza-anthraquinones
chromones
anti-proliferation agent
author_facet Jiaqi Yuan
Qian He
Shanshan Song
Xiaofei Zhang
Zehong Miao
Chunhao Yang
author_sort Jiaqi Yuan
title One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
title_short One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
title_full One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
title_fullStr One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
title_full_unstemmed One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
title_sort one pot and metal-free approach to 3-(2-hydroxybenzoyl)-1-aza-anthraquinones
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2019-08-01
description Herein, a direct strategy to synthesize 3-(2-hydroxybenzoyl)-1-aza-anthraquinones with excellent efficiency, mild conditions, and benign functional group compatibility was reported. A variety of 3-formylchromone compounds were employed as compatible substrates and this protocol gave the 3-(2-hydroxybenzoyl)-1-aza-anthraquinone derivatives in good to excellent yields without inert gas and expensive transition metal catalysts. Some compounds displayed good anti-proliferative activities.
topic 3-(2-hydroxybenzoyl)-1-aza-anthraquinones
chromones
anti-proliferation agent
url https://www.mdpi.com/1420-3049/24/16/3017
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