Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs

In fission yeast, several lncRNAs act in cis to regulate expression of adjacent genes. Here, the authors show that the conserved Pir2ARS2 protein is targeted, along with splicing factors, to cryptic introns in lncRNAs and recruits effectors, including RNAi machinery, for gene repression.

Bibliographic Details
Main Authors:	Gobi Thillainadesan, Hua Xiao, Sahana Holla, Jothy Dhakshnamoorthy, Lisa M. Miller Jenkins, David Wheeler, Shiv I. S. Grewal
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16280-y

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spelling	doaj-5700ae1f518e43c0ae8fc278a9926f5f2021-05-16T11:11:34ZengNature Publishing GroupNature Communications2041-17232020-05-0111111110.1038/s41467-020-16280-yConserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAsGobi Thillainadesan0Hua Xiao1Sahana Holla2Jothy Dhakshnamoorthy3Lisa M. Miller Jenkins4David Wheeler5Shiv I. S. Grewal6Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of HealthLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of HealthLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of HealthLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of HealthLaboratory of Cell Biology, National Cancer Institute, National Institutes of HealthLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of HealthLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of HealthIn fission yeast, several lncRNAs act in cis to regulate expression of adjacent genes. Here, the authors show that the conserved Pir2ARS2 protein is targeted, along with splicing factors, to cryptic introns in lncRNAs and recruits effectors, including RNAi machinery, for gene repression.https://doi.org/10.1038/s41467-020-16280-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Gobi Thillainadesan Hua Xiao Sahana Holla Jothy Dhakshnamoorthy Lisa M. Miller Jenkins David Wheeler Shiv I. S. Grewal
spellingShingle	Gobi Thillainadesan Hua Xiao Sahana Holla Jothy Dhakshnamoorthy Lisa M. Miller Jenkins David Wheeler Shiv I. S. Grewal Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs Nature Communications
author_facet	Gobi Thillainadesan Hua Xiao Sahana Holla Jothy Dhakshnamoorthy Lisa M. Miller Jenkins David Wheeler Shiv I. S. Grewal
author_sort	Gobi Thillainadesan
title	Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs
title_short	Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs
title_full	Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs
title_fullStr	Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs
title_full_unstemmed	Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs
title_sort	conserved protein pir2ars2 mediates gene repression through cryptic introns in lncrnas
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-05-01
description	In fission yeast, several lncRNAs act in cis to regulate expression of adjacent genes. Here, the authors show that the conserved Pir2ARS2 protein is targeted, along with splicing factors, to cryptic introns in lncRNAs and recruits effectors, including RNAi machinery, for gene repression.
url	https://doi.org/10.1038/s41467-020-16280-y
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Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs

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