Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs

Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs

In fission yeast, several lncRNAs act in cis to regulate expression of adjacent genes. Here, the authors show that the conserved Pir2ARS2 protein is targeted, along with splicing factors, to cryptic introns in lncRNAs and recruits effectors, including RNAi machinery, for gene repression.

Bibliographic Details
Main Authors: Gobi Thillainadesan, Hua Xiao, Sahana Holla, Jothy Dhakshnamoorthy, Lisa M. Miller Jenkins, David Wheeler, Shiv I. S. Grewal
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16280-y
Description
Summary:In fission yeast, several lncRNAs act in cis to regulate expression of adjacent genes. Here, the authors show that the conserved Pir2ARS2 protein is targeted, along with splicing factors, to cryptic introns in lncRNAs and recruits effectors, including RNAi machinery, for gene repression.
ISSN:2041-1723

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