Multimodal Ligand Binding Studies of Human and Mouse G-Coupled Taste Receptors to Correlate Their Species-Specific Sweetness Tasting Properties

Multimodal Ligand Binding Studies of Human and Mouse G-Coupled Taste Receptors to Correlate Their Species-Specific Sweetness Tasting Properties

Taste signaling is a complex process that is linked to obesity and its associated metabolic syndromes. The sweet taste is mediated through a heterodimeric G protein coupled receptor (GPCR) in a species-specific manner and at multi-tissue specific levels. The sweet receptor recognizes a large number...

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Bibliographic Details
Main Authors: Fariba M. Assadi-Porter, James Radek, Hongyu Rao, Marco Tonelli
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
G-coupled protein receptors (GPCRs)
sweet taste receptor
ligand binding
nuclear magnetic resonance spectroscopy (NMR)
saturation transfer difference (STD)-NMR
differential scanning calorimetry (DSC)
circular dichroism (CD) spectroscopy
intrinsic fluorescence spectroscopy (IF)
Online Access:http://www.mdpi.com/1420-3049/23/10/2531

Internet

http://www.mdpi.com/1420-3049/23/10/2531

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