Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

Glycoprotein ZP1 is a component of the oocyte’s zona pellucida (ZP), and mutations in human ZP1 are linked to female infertility. Here, using structure-function analysis, the authors suggest that filament cross-linking by ZP1 is required to form a stable ZP in human, and infertility mutations interf...

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Bibliographic Details
Main Authors: Kaoru Nishimura, Elisa Dioguardi, Shunsuke Nishio, Alessandra Villa, Ling Han, Tsukasa Matsuda, Luca Jovine
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10931-5

Internet

https://doi.org/10.1038/s41467-019-10931-5

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