Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

Glycoprotein ZP1 is a component of the oocyte’s zona pellucida (ZP), and mutations in human ZP1 are linked to female infertility. Here, using structure-function analysis, the authors suggest that filament cross-linking by ZP1 is required to form a stable ZP in human, and infertility mutations interf...

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Main Authors: Kaoru Nishimura, Elisa Dioguardi, Shunsuke Nishio, Alessandra Villa, Ling Han, Tsukasa Matsuda, Luca Jovine
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10931-5
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spelling doaj-56d66a23508b4bf9b30688e79a38ded72021-05-11T11:45:29ZengNature Publishing GroupNature Communications2041-17232019-07-0110111510.1038/s41467-019-10931-5Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertilityKaoru Nishimura0Elisa Dioguardi1Shunsuke Nishio2Alessandra Villa3Ling Han4Tsukasa Matsuda5Luca Jovine6Department of Biosciences and Nutrition and Center for Innovative Medicine, Karolinska InstitutetDepartment of Biosciences and Nutrition and Center for Innovative Medicine, Karolinska InstitutetDepartment of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya UniversityDepartment of Biosciences and Nutrition and Center for Innovative Medicine, Karolinska InstitutetDepartment of Biosciences and Nutrition and Center for Innovative Medicine, Karolinska InstitutetDepartment of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya UniversityDepartment of Biosciences and Nutrition and Center for Innovative Medicine, Karolinska InstitutetGlycoprotein ZP1 is a component of the oocyte’s zona pellucida (ZP), and mutations in human ZP1 are linked to female infertility. Here, using structure-function analysis, the authors suggest that filament cross-linking by ZP1 is required to form a stable ZP in human, and infertility mutations interfere with cross-linking.https://doi.org/10.1038/s41467-019-10931-5
collection DOAJ
language English
format Article
sources DOAJ
author Kaoru Nishimura
Elisa Dioguardi
Shunsuke Nishio
Alessandra Villa
Ling Han
Tsukasa Matsuda
Luca Jovine
spellingShingle Kaoru Nishimura
Elisa Dioguardi
Shunsuke Nishio
Alessandra Villa
Ling Han
Tsukasa Matsuda
Luca Jovine
Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
Nature Communications
author_facet Kaoru Nishimura
Elisa Dioguardi
Shunsuke Nishio
Alessandra Villa
Ling Han
Tsukasa Matsuda
Luca Jovine
author_sort Kaoru Nishimura
title Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
title_short Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
title_full Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
title_fullStr Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
title_full_unstemmed Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
title_sort molecular basis of egg coat cross-linking sheds light on zp1-associated female infertility
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-07-01
description Glycoprotein ZP1 is a component of the oocyte’s zona pellucida (ZP), and mutations in human ZP1 are linked to female infertility. Here, using structure-function analysis, the authors suggest that filament cross-linking by ZP1 is required to form a stable ZP in human, and infertility mutations interfere with cross-linking.
url https://doi.org/10.1038/s41467-019-10931-5
work_keys_str_mv AT kaorunishimura molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility
AT elisadioguardi molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility
AT shunsukenishio molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility
AT alessandravilla molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility
AT linghan molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility
AT tsukasamatsuda molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility
AT lucajovine molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility
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