Tgf-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma.

The TGF-beta family of mediators are thought to play important roles in the regulation of inflammation and airway remodelling in asthma. All three mammalian isoforms of TGF-beta, TGF-beta(1-3), are expressed in the airways and TGF-beta(1) and -beta(2) are increased in asthma. However, there is littl...

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Bibliographic Details
Main Authors: Stephen E Bottoms, Jane E Howell, Alistair K Reinhardt, Iona C Evans, Robin J McAnulty
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2837347?pdf=render