Extracellular proteolysis of apolipoprotein E (apoE) by secreted serine neuronal protease.

Extracellular proteolysis of apolipoprotein E (apoE) by secreted serine neuronal protease.

Under normal conditions, brain apolipoprotein E (apoE) is secreted and lipidated by astrocytes, then taken up by neurons via receptor mediated endocytosis. Free apoE is either degraded in intraneuronal lysosomal compartments or released. Here we identified a novel way by which apoE undergoes proteol...

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Bibliographic Details
Main Authors: Irfan Y Tamboli, Dongeun Heo, G William Rebeck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3968057?pdf=render

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