IL-1 in osteoarthritis: time for a critical review of the literature [version 1; peer review: 2 approved]
The concept of interleukin-1 (IL-1) as a target in osteoarthritis (OA) has been an attractive one for many years. It is a highly potent inducer of cartilage degradation, causing the induction of mRNA and controlling the bioavailability of disease-relevant proteases such as ADAMTS5 and MMP13. It driv...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2019-06-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/8-934/v1 |