Brain Edema Formation and Functional Outcome After Surgical Decompression in Murine Closed Head Injury Are Modulated by Acetazolamide Administration

Brain Edema Formation and Functional Outcome After Surgical Decompression in Murine Closed Head Injury Are Modulated by Acetazolamide Administration

Acetazolamide (ACZ), carbonic anhydrase inhibitor, has been successfully applied in several neurosurgical conditions for diagnostic or therapeutic purposes. Furthermore, neuroprotective and anti-edematous properties of ACZ have been postulated. However, its use in traumatic brain injury (TBI) is lim...

Full description

Bibliographic Details
Main Authors: Jacek Szczygielski, Vanessa Hubertus, Eduard Kruchten, Andreas Müller, Lisa Franziska Albrecht, Angelika E. Mautes, Karsten Schwerdtfeger, Joachim Oertel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Neurology
Subjects:
traumatic brain injury
acetazolamide
decompressive craniectomy
brain edema
mouse
closed head injury
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00273/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2019.00273/full

Similar Items