(+)-JQ1 attenuated LPS-induced microglial inflammation via MAPK/NFκB signaling

(+)-JQ1 attenuated LPS-induced microglial inflammation via MAPK/NFκB signaling

Abstract Background Microglia activation is a crucial event in neurodegenerative disease. The depression of microglial inflammatory response is considered a promising therapeutic strategy. NFκB signaling, including IKK/IκB phosphotylation, p65 nucelus relocalization and NFκB-related genes transcript...

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Main Authors: Huanhuan Wang, Wenhai Huang, Meihao Liang, Yingying Shi, Chixiao Zhang, Qin Li, Meng Liu, Yikai Shou, Hongping Yin, Xiaozheng Zhu, Xiaoyan Sun, Yu Hu, Zhengrong Shen
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Cell & Bioscience
Subjects:
(+)-JQ1
Microglia
Lipopolysaccharide
MAPK
NFκB
Online Access:http://link.springer.com/article/10.1186/s13578-018-0258-7

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