Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis

Cystic fibrosis (CF) is one of the most common inherited diseases and is caused by mutations in the CFTR gene. Although the pulmonary and gastrointestinal manifestations of the disease remain in the focus of treatment, recent studies have shown expression of the CFTR gene product in skeletal muscle...

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Main Authors:	Henning Neubauer, Clemens Wirth, Katharina Ruf, Helge Hebestreit, Meinrad Beer
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	Case Reports in Pediatrics
Online Access:	http://dx.doi.org/10.1155/2012/527989

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spelling	doaj-56aff6d5650b40a58a964ac0b47cc64b2020-11-24T21:20:17ZengHindawi LimitedCase Reports in Pediatrics2090-68032090-68112012-01-01201210.1155/2012/527989527989Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic FibrosisHenning Neubauer0Clemens Wirth1Katharina Ruf2Helge Hebestreit3Meinrad Beer4Department of Paediatric Radiology, Institute of Radiology, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080 Wuerzburg, GermanyDepartment of Paediatric Radiology, Institute of Radiology, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080 Wuerzburg, GermanyDepartment of Paediatrics, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080 Wuerzburg, GermanyDepartment of Paediatrics, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080 Wuerzburg, GermanyDepartment of Paediatric Radiology, Institute of Radiology, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080 Wuerzburg, GermanyCystic fibrosis (CF) is one of the most common inherited diseases and is caused by mutations in the CFTR gene. Although the pulmonary and gastrointestinal manifestations of the disease remain in the focus of treatment, recent studies have shown expression of the CFTR gene product in skeletal muscle cells and observed altered intramuscular Ca2+ release dynamics in CFTR-deficient animal models. Physical exercise is beneficial for maintaining fitness and well-being in CF patients and constitutes one aspect of modern multimodal treatment, which has considerably increased life span and reduced morbidity. We report on a case of acute muscle trauma resulting from excessive dumbbell exercise in a young adult with cystic fibrosis and describe clinical, laboratory and imaging characteristics of acute exercise-induced muscle injury.http://dx.doi.org/10.1155/2012/527989
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Henning Neubauer Clemens Wirth Katharina Ruf Helge Hebestreit Meinrad Beer
spellingShingle	Henning Neubauer Clemens Wirth Katharina Ruf Helge Hebestreit Meinrad Beer Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis Case Reports in Pediatrics
author_facet	Henning Neubauer Clemens Wirth Katharina Ruf Helge Hebestreit Meinrad Beer
author_sort	Henning Neubauer
title	Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis
title_short	Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis
title_full	Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis
title_fullStr	Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis
title_full_unstemmed	Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis
title_sort	acute muscle trauma due to overexercise in an otherwise healthy patient with cystic fibrosis
publisher	Hindawi Limited
series	Case Reports in Pediatrics
issn	2090-6803 2090-6811
publishDate	2012-01-01
description	Cystic fibrosis (CF) is one of the most common inherited diseases and is caused by mutations in the CFTR gene. Although the pulmonary and gastrointestinal manifestations of the disease remain in the focus of treatment, recent studies have shown expression of the CFTR gene product in skeletal muscle cells and observed altered intramuscular Ca2+ release dynamics in CFTR-deficient animal models. Physical exercise is beneficial for maintaining fitness and well-being in CF patients and constitutes one aspect of modern multimodal treatment, which has considerably increased life span and reduced morbidity. We report on a case of acute muscle trauma resulting from excessive dumbbell exercise in a young adult with cystic fibrosis and describe clinical, laboratory and imaging characteristics of acute exercise-induced muscle injury.
url	http://dx.doi.org/10.1155/2012/527989
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Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis

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