A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability

A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability

Various lncRNAs functions have been associated to replication stress and DNA double strand breaks in ESC. Here the authors reveal the lncRNA Discn-NCL-RPA axis pathway, which can regulate the availability of RPA pool for DNA replication stress response and repair.

Bibliographic Details
Main Authors: Lin Wang, Jingzheng Li, Hu Zhou, Weidao Zhang, Jing Gao, Ping Zheng
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25827-6
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spelling doaj-56a478158e624d08ac79bc64bc5d94832021-09-26T11:45:33ZengNature Publishing GroupNature Communications2041-17232021-09-0112111510.1038/s41467-021-25827-6A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stabilityLin Wang0Jingzheng Li1Hu Zhou2Weidao Zhang3Jing Gao4Ping Zheng5State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesDepartment of Analytical Chemistry and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesDepartment of Analytical Chemistry and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesVarious lncRNAs functions have been associated to replication stress and DNA double strand breaks in ESC. Here the authors reveal the lncRNA Discn-NCL-RPA axis pathway, which can regulate the availability of RPA pool for DNA replication stress response and repair.https://doi.org/10.1038/s41467-021-25827-6
collection DOAJ
language English
format Article
sources DOAJ
author Lin Wang
Jingzheng Li
Hu Zhou
Weidao Zhang
Jing Gao
Ping Zheng
spellingShingle Lin Wang
Jingzheng Li
Hu Zhou
Weidao Zhang
Jing Gao
Ping Zheng
A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability
Nature Communications
author_facet Lin Wang
Jingzheng Li
Hu Zhou
Weidao Zhang
Jing Gao
Ping Zheng
author_sort Lin Wang
title A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability
title_short A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability
title_full A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability
title_fullStr A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability
title_full_unstemmed A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability
title_sort novel lncrna discn fine-tunes replication protein a (rpa) availability to promote genomic stability
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-09-01
description Various lncRNAs functions have been associated to replication stress and DNA double strand breaks in ESC. Here the authors reveal the lncRNA Discn-NCL-RPA axis pathway, which can regulate the availability of RPA pool for DNA replication stress response and repair.
url https://doi.org/10.1038/s41467-021-25827-6
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