Using historical data to facilitate clinical prevention trials in Alzheimer disease? An analysis of longitudinal MCI (mild cognitive impairment) data sets

Using historical data to facilitate clinical prevention trials in Alzheimer disease? An analysis of longitudinal MCI (mild cognitive impairment) data sets

Abstract Background The Placebo Group Simulation Approach (PGSA) aims at partially replacing randomized placebo-controlled trials (RPCTs), making use of data from historical control groups in order to decrease the needed number of study participants exposed to lengthy placebo treatment. PGSA algorit...

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Bibliographic Details
Main Authors: Manfred Berres, Andreas U. Monsch, René Spiegel
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Historical controls
MCI criteria
Clinical trial
Cohort study
Convenience sample
Meta-analysis
Online Access:https://doi.org/10.1186/s13195-021-00832-5

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