Promethazine protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity

Promethazine protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity

Promethazine (PMZ) is an FDA-approved antihistaminergic drug that was identified as a potentially neuroprotective compound in the NINDS screening program. PMZ accumulates in brain mitochondria in vivo and inhibits Ca2+-induced mitochondrial permeability transition pore (PTP) in rat liver mitochondri...

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Bibliographic Details
Main Authors:	Carine Cleren, Anatoly A. Starkov, Noel Y. Calingasan, Beverly J. Lorenzo, Junya Chen, M. Flint Beal
Format:	Article
Language:	English
Published:	Elsevier 2005-12-01
Series:	Neurobiology of Disease
Subjects:	Promethazine MPTP MPP+ Parkinson Neuroprotection Mitochondria
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996105001397

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