Transcriptional Inhibition of lncRNA gadd7 by CRISPR/dCas9-KRAB Protects Spermatocyte Viability

Transcriptional Inhibition of lncRNA gadd7 by CRISPR/dCas9-KRAB Protects Spermatocyte Viability

Our previous study found that lncRNA gadd7 was up-regulated in the semen of varicocele patients, and could promote the apoptosis of mouse spermatocytes and inhibit their proliferation. Therefore, we further explored whether down-regulation of Gadd seven expression could protect the viability of sper...

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Bibliographic Details
Main Authors: Jun Zhao, Wenmin Ma, Yucheng Zhong, Hao Deng, Bingyu Zhou, Yaqin Wu, Meiqiong Yang, Huan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
lncRNA gadd7
CRISPR
varicocele
infertility
male
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.652392/full

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