TYPE 1 DIABETES AND INSULIN RESISTANCE: ESTIMATED GLUCOSE DISPOSAL RATE AND ITS CORRELATION WITH CHRONIC COMPLICATIONS

• Main Authors: Gabriela Caeiro, Silvana A Romero Gónzalez, Jimena Itria, Jorge Waitman
• Format: Article
• Language: Spanish
• Published: Sello Editorial Lugones 2018-07-01
• Series: Revista de la Sociedad Argentina de Diabetes
• Subjects: diabetes mellitus tipo 1; resistencia a la insulina; complicaciones de la diabetes
• Online Access: https://www.revistasad.com/index.php/diabetes/article/view/53

Introduction: insulin resistance (IR) in type 1 diabetes (T1D) is associated with a higher risk of complications in these patients. The gold standard for measuring insulin sensitivity is the hyperinsulinemic-euglycemic clamp although not used in clinical practice. The estimated glucose disposal rate (eGDR) has been validated to estimate insulin sensitivity. Objectives: the objective was to correlate IR in T1D (eGDR), with macro and microvascular complications in patients assisted in a Diabetology Service. Materials and methods: we performed a cross-sectional study. The eGDR was calculated using HbA1c, waist circumference, and hypertensive status.