Trienone analogs of curcuminoids induce fetal hemoglobin synthesis via demethylation at Gγ-globin gene promoter

Trienone analogs of curcuminoids induce fetal hemoglobin synthesis via demethylation at Gγ-globin gene promoter

Abstract The reactivation of γ-globin chain synthesis to combine with excess free α-globin chains and form fetal hemoglobin (HbF) is an important alternative treatment for β-thalassemia. We had reported HbF induction property of natural curcuminoids, curcumin (Cur), demethoxycurcumin (DMC) and bis-d...

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Bibliographic Details
Main Authors: Khanita Nuamsee, Thipphawan Chuprajob, Wachirachai Pabuprapap, Pornrutsami Jintaridth, Thongperm Munkongdee, Phatchariya Phannasil, Jim Vadolas, Pornthip Chaichompoo, Apichart Suksamrarn, Saovaros Svasti
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-87738-2

Internet

https://doi.org/10.1038/s41598-021-87738-2

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