ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria

ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria

Structural and functional analysis of mitochondria from the human parasite Toxoplasma gondii reveals that its ATP synthase assembles into cyclic hexamers, arranged together in a form of pentagonal pyramids required for maintenance of cristae morphology in Apicomplexa.

Bibliographic Details
Main Authors: Alexander Mühleip, Rasmus Kock Flygaard, Jana Ovciarikova, Alice Lacombe, Paula Fernandes, Lilach Sheiner, Alexey Amunts
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20381-z
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spelling doaj-56947c119cc747a6b15d66b6a21394402021-01-10T12:18:46ZengNature Publishing GroupNature Communications2041-17232021-01-0112111310.1038/s41467-020-20381-zATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondriaAlexander Mühleip0Rasmus Kock Flygaard1Jana Ovciarikova2Alice Lacombe3Paula Fernandes4Lilach Sheiner5Alexey Amunts6Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm UniversityScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm UniversityWellcome Centre for Integrative Parasitology, University of GlasgowWellcome Centre for Integrative Parasitology, University of GlasgowScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm UniversityWellcome Centre for Integrative Parasitology, University of GlasgowScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm UniversityStructural and functional analysis of mitochondria from the human parasite Toxoplasma gondii reveals that its ATP synthase assembles into cyclic hexamers, arranged together in a form of pentagonal pyramids required for maintenance of cristae morphology in Apicomplexa.https://doi.org/10.1038/s41467-020-20381-z
collection DOAJ
language English
format Article
sources DOAJ
author Alexander Mühleip
Rasmus Kock Flygaard
Jana Ovciarikova
Alice Lacombe
Paula Fernandes
Lilach Sheiner
Alexey Amunts
spellingShingle Alexander Mühleip
Rasmus Kock Flygaard
Jana Ovciarikova
Alice Lacombe
Paula Fernandes
Lilach Sheiner
Alexey Amunts
ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria
Nature Communications
author_facet Alexander Mühleip
Rasmus Kock Flygaard
Jana Ovciarikova
Alice Lacombe
Paula Fernandes
Lilach Sheiner
Alexey Amunts
author_sort Alexander Mühleip
title ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria
title_short ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria
title_full ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria
title_fullStr ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria
title_full_unstemmed ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria
title_sort atp synthase hexamer assemblies shape cristae of toxoplasma mitochondria
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-01-01
description Structural and functional analysis of mitochondria from the human parasite Toxoplasma gondii reveals that its ATP synthase assembles into cyclic hexamers, arranged together in a form of pentagonal pyramids required for maintenance of cristae morphology in Apicomplexa.
url https://doi.org/10.1038/s41467-020-20381-z
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