Reliable Generation of Native-Like Decoys Limits Predictive Ability in Fragment-Based Protein Structure Prediction

Reliable Generation of Native-Like Decoys Limits Predictive Ability in Fragment-Based Protein Structure Prediction

Our previous work with fragment-assembly methods has demonstrated specific deficiencies in conformational sampling behaviour that, when addressed through improved sampling algorithms, can lead to more reliable prediction of tertiary protein structure when good fragments are available, and when score...

Full description

Bibliographic Details
Main Authors: Shaun M. Kandathil, Mario Garza-Fabre, Julia Handl, Simon C. Lovell
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Biomolecules
Subjects:
protein structure prediction
fragment assembly
conformational sampling
stochastic ranking
Online Access:https://www.mdpi.com/2218-273X/9/10/612

Similar Items

Similar Items