Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance in drug-adapted cancer cells

Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance in drug-adapted cancer cells

Resistance to systemic drug therapy is a major reason for the failure of anticancer therapies. Here, we tested doxorubicin-loaded human serum albumin (HSA) nanoparticles in the neuroblastoma cell line UKF-NB-3 and its ABCB1-expressing sublines adapted to vincristine (UKF-NB-3rVCR1) and doxorubicin (...

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Bibliographic Details
Main Authors: Hannah Onafuye, Sebastian Pieper, Dennis Mulac, Jindrich Cinatl Jr., Mark N. Wass, Klaus Langer, Martin Michaelis
Format: Article
Language:English
Published: Beilstein-Institut 2019-08-01
Series:Beilstein Journal of Nanotechnology
Subjects:
ABCB1
cancer
doxorubicin
drug resistance
human serum albumin
nanoparticles
transporter
Online Access:https://doi.org/10.3762/bjnano.10.166

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