Computational Prediction of O-linked Glycosylation Sites that Preferentially Map on Intrinsically Disordered Regions of Extracellular Proteins

Computational Prediction of O-linked Glycosylation Sites that Preferentially Map on Intrinsically Disordered Regions of Extracellular Proteins

O-glycosylation of mammalian proteins is one of the important posttranslational modifications. We applied a support vector machine (SVM) to predict whether Ser or Thr is glycosylated, in order to elucidate the O-glycosylation mechanism. O-glycosylated sites were often found clustered along the seque...

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Bibliographic Details
Main Authors: Satoshi Fukuchi, Ken Nishikawa, Keiichi Homma, Masahiro Ito, Ikuko Nishikawa, Yukiko Nakajima
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:International Journal of Molecular Sciences
Subjects:
protein O-glycosylation
mucin-type
posttranslational modification
support vector machine
clustered and isolated glycosylation sites
intrinsically disordered
extracellular protein
non-conservation property
Online Access:http://www.mdpi.com/1422-0067/11/12/4991/

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