Immunization with Epstein–Barr Virus Core Fusion Machinery Envelope Proteins Elicit High Titers of Neutralizing Activities and Protect Humanized Mice from Lethal Dose EBV Challenge

Immunization with Epstein–Barr Virus Core Fusion Machinery Envelope Proteins Elicit High Titers of Neutralizing Activities and Protect Humanized Mice from Lethal Dose EBV Challenge

Epstein–Barr virus (EBV) is the primary cause of infectious mononucleosis and is strongly implicated in the etiology of multiple lymphoid and epithelial cancers. EBV core fusion machinery envelope proteins gH/gL and gB coordinately mediate EBV fusion and entry into its target cells, B lymphocytes an...

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Bibliographic Details
Main Authors: Xinle Cui, Zhouhong Cao, Yuriko Ishikawa, Sara Cui, Ken-Ichi Imadome, Clifford M. Snapper
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Vaccines
Subjects:
Epstein–Barr virus
infectious mononucleosis
EBV-associated lymphoma and epithelial cancer
EBV vaccine development
core fusion machinery
envelope glycoprotein
Online Access:https://www.mdpi.com/2076-393X/9/3/285

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