Immunohistochemical Studies of the Kynurenine Pathway in Morphea

Immunohistochemical Studies of the Kynurenine Pathway in Morphea

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Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, ski...

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Main Authors: Rowland Noakes, Nick Mellick
Format: Article
Language:English
Published: SAGE Publishing 2013-01-01
Series:International Journal of Tryptophan Research
Online Access:https://doi.org/10.4137/IJTR.S13371
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spelling doaj-566bdbc56fa347edb1128f44e48f46242020-11-25T04:08:57ZengSAGE PublishingInternational Journal of Tryptophan Research1178-64692013-01-01610.4137/IJTR.S13371Immunohistochemical Studies of the Kynurenine Pathway in MorpheaRowland Noakes0Nick Mellick1Queensland Institute of Dermatology, Holland Park, Australia.Zenith Specialist Pathology, South Brisbane, Queensland, Australia.Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, skin biopsies were taken from involved and non-involved sites in a series of three patients with morphea. Immunohistochemical stains for quinolinic acid and indoleamine 2,3-dioxygenase (IDO) were performed.https://doi.org/10.4137/IJTR.S13371
collection DOAJ
language English
format Article
sources DOAJ
author Rowland Noakes
Nick Mellick
spellingShingle Rowland Noakes
Nick Mellick
Immunohistochemical Studies of the Kynurenine Pathway in Morphea
International Journal of Tryptophan Research
author_facet Rowland Noakes
Nick Mellick
author_sort Rowland Noakes
title Immunohistochemical Studies of the Kynurenine Pathway in Morphea
title_short Immunohistochemical Studies of the Kynurenine Pathway in Morphea
title_full Immunohistochemical Studies of the Kynurenine Pathway in Morphea
title_fullStr Immunohistochemical Studies of the Kynurenine Pathway in Morphea
title_full_unstemmed Immunohistochemical Studies of the Kynurenine Pathway in Morphea
title_sort immunohistochemical studies of the kynurenine pathway in morphea
publisher SAGE Publishing
series International Journal of Tryptophan Research
issn 1178-6469
publishDate 2013-01-01
description Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, skin biopsies were taken from involved and non-involved sites in a series of three patients with morphea. Immunohistochemical stains for quinolinic acid and indoleamine 2,3-dioxygenase (IDO) were performed.
url https://doi.org/10.4137/IJTR.S13371
work_keys_str_mv AT rowlandnoakes immunohistochemicalstudiesofthekynureninepathwayinmorphea
AT nickmellick immunohistochemicalstudiesofthekynureninepathwayinmorphea
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