Genomic Profiling Reveals the Molecular Landscape of Gastrointestinal Tract Cancers in Chinese Patients

Genomic Profiling Reveals the Molecular Landscape of Gastrointestinal Tract Cancers in Chinese Patients

Gastrointestinal tract cancers have high incidence and mortality in China, but their molecular characteristics have not been fully investigated. We sequenced 432 tumor samples from the colorectum, stomach, pancreas, gallbladder, and biliary tract to investigate cancer-related mutations and detail th...

Full description

Bibliographic Details
Main Authors:	Chunrong Zhu, Liangjun Zhu, Yanhong Gu, Ping Liu, Xiaoling Tong, Guozhong Wu, Wenyu Zhu, Wenxiang Shen, Hua Bao, Xiangyuan Ma, Ruoying Yu, Xue Wu, Dongqin Zhu, Yongqian Shu, Jifeng Feng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Genetics
Subjects:	gastrointestinal cancers colorectal cancer gastric cancer tumor mutation load microsatellite instability chromosomal instability
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2021.608742/full

Similar Items

Management of Non-Colorectal Digestive Cancers with Microsatellite Instability
by: Mojun Zhu, et al.
Published: (2021-02-01)

Genetic instability in urinary bladder cancer: An evolving hallmark
by: N Wadhwa, et al.
Published: (2013-01-01)

Immunohistochemical pattern– a prognostic factor for synchronous gastrointestinal cancer
by: Catalin Alius, et al.
Published: (2020-10-01)

Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements
by: Ahmed Malki, et al.
Published: (2021-12-01)

Molecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention
by: Luigi Ricciardiello, et al.
Published: (2013-08-01)

An Investigator-Initiated Phase 2 Study of Nivolumab Plus Low-Dose Ipilimumab as First-Line Therapy for Microsatellite Instability—High Advanced Gastric or Esophagogastric Junction Cancer (NO LIMIT, WJOG13320G/CA209-7W7)
by: Hisato Kawakami, et al.
Published: (2021-02-01)

Colorectal Cancers: An Update on Their Molecular Pathology
by: Kentaro Inamura
Published: (2018-01-01)

Intrinsic structural variation of the complex microsatellite marker MYCL1 in Finnish and Somali populations and its relevance to gastrointestinal tumors
by: Hanna Vauhkonen, et al.
Published: (2006-01-01)

Implication of Microsatellite Instability in Chinese Cohort of Human Cancers
by: Cui M, et al.
Published: (2020-10-01)

A greater lymph node yield is required during pathological examination in microsatellite instability-high gastric cancer
by: Zhenghao Cai, et al.
Published: (2021-03-01)

Occurrence of High Microsatellite-Instability/Mismatch Repair Deficiency in Nearly 2,000 Human Adenocarcinomas of the Gastrointestinal Tract, Pancreas, and Bile Ducts: A Study From a Large German Comprehensive Cancer Center
by: Alexander Quaas, et al.
Published: (2021-07-01)

Colorectal cancer carcinogenesis: a review of mechanisms
by: Kanwal Tariq, et al.
Published: (2016-03-01)

Clinical and morphological portrait of tumors with microsatellite instability
by: A. A. Musaelyan, et al.
Published: (2021-07-01)

From Tumor Immunology to Immunotherapy in Gastric and Esophageal Cancer
by: David Vrána, et al.
Published: (2018-12-01)

Association Between the Microsatellite Instability Status and the Efficacy of Postoperative Adjuvant Chemoradiotherapy in Patients With Gastric Cancer
by: Dongfang Dai, et al.
Published: (2020-01-01)

Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8
by: GiWon Shin, et al.
Published: (2021-09-01)

Mismatch Repair System Genomic Scars in Gastroesophageal Cancers: Biology and Clinical Testing
by: Gianluca Lopez, et al.
Published: (2020-09-01)

Acute Tumor Transition Angle on Computed Tomography Predicts Chromosomal Instability Status of Primary Gastric Cancer: Radiogenomics Analysis from TCGA and Independent Validation
by: Ying-Chieh Lai, et al.
Published: (2019-05-01)

Molecular classification of esophagogastric junction carcinoma correlated with prognosis
by: Zou L, et al.
Published: (2017-09-01)

Prophylactic chemotherapeutic hyperthermic intraperitoneal perfusion reduces peritoneal metastasis in gastric cancer: a retrospective clinical study
by: Lucheng Zhu, et al.
Published: (2020-08-01)

Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancer
by: Johanna Kondelin, et al.
Published: (2018-09-01)

Clinicopathologic features of colorectal carcinoma: features predicting higher T-stage and nodal metastasis
by: Atif Ali Hashmi, et al.
Published: (2018-01-01)

Microsatellite Status Affects Tumor Response and Survival in Patients Undergoing Neoadjuvant Chemotherapy for Clinical Stage III Gastric Cancer
by: Zhenghao Cai, et al.
Published: (2020-12-01)

A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability
by: Bernardo eOrr, et al.
Published: (2013-06-01)

Re‐exposure to immunotherapy in metastatic colon cancer: A case report
by: Tonje Riise Hamre, et al.
Published: (2021-06-01)

Unexpected tumor response to palliative pelvic radiotherapy in mismatch repair-deficient advanced prostate cancer: a case report
by: Giovanni Aluisio, et al.
Published: (2020-12-01)

Pembrolizumab for a patient with metastatic castration‐resistant prostate cancer with microsatellite instability‐high
by: Motohiro Fujiwara, et al.
Published: (2020-03-01)

Impact of microsatellite instability on survival of endometrial cancer patients
by: Daiva Kanopienė, et al.
Published: (2014-01-01)

Rapid Response to Pembrolizumab in a Chemo-Refractory Testicular Germ Cell Cancer with Microsatellite Instability-High
by: Kawai K, et al.
Published: (2021-09-01)

Durable response to programmed death-1 (PD-1) blockade in a metastatic gastric cancer patient with mismatch repair deficiency and microsatellite instability
by: Ting-Hui Wu, et al.
Published: (2017-06-01)

Gastric cancer is associated with a high rate of microsatellite instability versus chronic gastritis: A retrospective study
by: Xing Li, et al.
Published: (2020-01-01)

Clinical Application of Genetics in Management of Colorectal Cancer
by: Eun Ran Kim, et al.
Published: (2014-07-01)

Clinical Aspects of Microsatellite Instability Testing in Colorectal Cancer
by: Mehrdad Zeinalian, et al.
Published: (2018-01-01)

Influence of MSI and 18q LOH markers on capecitabine adjuvant monotherapy in colon cancer patients
by: Matevska-Geshkovska N, et al.
Published: (2018-11-01)

Pathological Complete Response After a Single Dose of Anti-PD-1 Therapy in Combination with Chemotherapy as a First-Line Setting in an Unresectable Locally Advanced Gastric Cancer with PD-L1 Positive and Microsatellite Instability
by: Jin H, et al.
Published: (2020-02-01)

Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development
by: Aner Mesic, et al.
Published: (2019-09-01)

Screening of MSI detection loci and their heterogeneity in East Asian colorectal cancer patients
by: Wenqi Bai, et al.
Published: (2019-05-01)

Computed Tomography Features of Gastric Cancer Patients With DNA Mismatch Repair Deficiency
by: Qian Cao, et al.
Published: (2021-03-01)

The Better Survival of MSI Subtype Is Associated With the Oxidative Stress Related Pathways in Gastric Cancer
by: Lei Cai, et al.
Published: (2020-07-01)

Her2-Positive and Microsatellite Instability Status in Gastric Cancer—Clinicopathological Implications
by: Ana Bermúdez, et al.
Published: (2021-05-01)