Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario

Introduction: The role of Vascular Endothelial Growth Factor (VEGF) in angiogenesis has been extensively studied in gliomas, such as astrocytoma and oligodendrogliomas, worldwide. However, there is limited information available with regard to the Indian population. Aim: To study, whether VEGF i...

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Main Authors: Ramya S Vokuda, Bheemanathi Hanuman Srinivas, Venkatesh S Madhugiri, Surendra Kumar Verma
Format: Article
Language:English
Published: JCDR Research and Publications Private Limited 2017-02-01
Series:Journal of Clinical and Diagnostic Research
Subjects:
Online Access:https://jcdr.net/articles/PDF/9331/24353_CE[Ra1]_F(GH)_PF1(PI_RK)_PFA(AK)_PF2(P_RB)_PF3(AG_OM).pdf
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spelling doaj-56664c1073d04f15a6c1b7f48e7ca5f12020-11-25T02:54:26ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-02-01112EC05EC0710.7860/JCDR/2017/24353.9331Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian ScenarioRamya S Vokuda0Bheemanathi Hanuman Srinivas1Venkatesh S Madhugiri2Surendra Kumar Verma3PhD Research Scholar, Department of Pathology, Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER), Puducherry, India.Assistant Professor, Department of Pathology, Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER), Puducherry, India.Associate Professor, Department of Neurosurgery, Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER), Puducherry, India.Professor, Department of Pathology, Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER), Puducherry, India.Introduction: The role of Vascular Endothelial Growth Factor (VEGF) in angiogenesis has been extensively studied in gliomas, such as astrocytoma and oligodendrogliomas, worldwide. However, there is limited information available with regard to the Indian population. Aim: To study, whether VEGF is expressed in the Indian population in a pattern similar to that in other population. Materials and Methods: In this prospective study approved by the Institute Ethics Committee for Human Studies at Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER) the patients operated for glioma in 2014 and 2015 (n = 60) were included. Tumours were graded as per the World Health Organization (WHO) grading system. VEGF expression in various grades was analysed using immunohistochemistry. Results: Of the 60 patients included in this study, 15 were Grade II- (diffuse astrocytomas – 12; oligodendrogliomas- 3), 15 were Grade III-(anaplastic astrocytomas- 2; anaplastic oligodendrogliomas – 13) and 30 were Grade IV-glioblastomas. For VEGF antibody staining, two patients (3.33%) showed negative results and 58 patients (96%) showed positive results. VEGF positivity was 100% in Grade II and III, while it was 93.3% (28/30) in Grade IV tumours (p=0.012). Conclusion: The expression of VEGF was associated with the grade of tumour, which gradually increased from Grade II to Grade IV. We conclude that VEGF-regulated angiogenesis plays an important role in tumour progression of astrocytomas and oligodendrogliomas in the Indian population as observed worldwide.https://jcdr.net/articles/PDF/9331/24353_CE[Ra1]_F(GH)_PF1(PI_RK)_PFA(AK)_PF2(P_RB)_PF3(AG_OM).pdfangiogenesisastrocytic tumoursglial tumours
collection DOAJ
language English
format Article
sources DOAJ
author Ramya S Vokuda
Bheemanathi Hanuman Srinivas
Venkatesh S Madhugiri
Surendra Kumar Verma
spellingShingle Ramya S Vokuda
Bheemanathi Hanuman Srinivas
Venkatesh S Madhugiri
Surendra Kumar Verma
Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario
Journal of Clinical and Diagnostic Research
angiogenesis
astrocytic tumours
glial tumours
author_facet Ramya S Vokuda
Bheemanathi Hanuman Srinivas
Venkatesh S Madhugiri
Surendra Kumar Verma
author_sort Ramya S Vokuda
title Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario
title_short Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario
title_full Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario
title_fullStr Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario
title_full_unstemmed Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario
title_sort vascular endothelial growth factor as an angiogenic marker in malignant astrocytoma and oligodendroglioma: an indian scenario
publisher JCDR Research and Publications Private Limited
series Journal of Clinical and Diagnostic Research
issn 2249-782X
0973-709X
publishDate 2017-02-01
description Introduction: The role of Vascular Endothelial Growth Factor (VEGF) in angiogenesis has been extensively studied in gliomas, such as astrocytoma and oligodendrogliomas, worldwide. However, there is limited information available with regard to the Indian population. Aim: To study, whether VEGF is expressed in the Indian population in a pattern similar to that in other population. Materials and Methods: In this prospective study approved by the Institute Ethics Committee for Human Studies at Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER) the patients operated for glioma in 2014 and 2015 (n = 60) were included. Tumours were graded as per the World Health Organization (WHO) grading system. VEGF expression in various grades was analysed using immunohistochemistry. Results: Of the 60 patients included in this study, 15 were Grade II- (diffuse astrocytomas – 12; oligodendrogliomas- 3), 15 were Grade III-(anaplastic astrocytomas- 2; anaplastic oligodendrogliomas – 13) and 30 were Grade IV-glioblastomas. For VEGF antibody staining, two patients (3.33%) showed negative results and 58 patients (96%) showed positive results. VEGF positivity was 100% in Grade II and III, while it was 93.3% (28/30) in Grade IV tumours (p=0.012). Conclusion: The expression of VEGF was associated with the grade of tumour, which gradually increased from Grade II to Grade IV. We conclude that VEGF-regulated angiogenesis plays an important role in tumour progression of astrocytomas and oligodendrogliomas in the Indian population as observed worldwide.
topic angiogenesis
astrocytic tumours
glial tumours
url https://jcdr.net/articles/PDF/9331/24353_CE[Ra1]_F(GH)_PF1(PI_RK)_PFA(AK)_PF2(P_RB)_PF3(AG_OM).pdf
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