Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario
Introduction: The role of Vascular Endothelial Growth Factor (VEGF) in angiogenesis has been extensively studied in gliomas, such as astrocytoma and oligodendrogliomas, worldwide. However, there is limited information available with regard to the Indian population. Aim: To study, whether VEGF i...
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doaj-56664c1073d04f15a6c1b7f48e7ca5f12020-11-25T02:54:26ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-02-01112EC05EC0710.7860/JCDR/2017/24353.9331Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian ScenarioRamya S Vokuda0Bheemanathi Hanuman Srinivas1Venkatesh S Madhugiri2Surendra Kumar Verma3PhD Research Scholar, Department of Pathology, Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER), Puducherry, India.Assistant Professor, Department of Pathology, Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER), Puducherry, India.Associate Professor, Department of Neurosurgery, Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER), Puducherry, India.Professor, Department of Pathology, Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER), Puducherry, India.Introduction: The role of Vascular Endothelial Growth Factor (VEGF) in angiogenesis has been extensively studied in gliomas, such as astrocytoma and oligodendrogliomas, worldwide. However, there is limited information available with regard to the Indian population. Aim: To study, whether VEGF is expressed in the Indian population in a pattern similar to that in other population. Materials and Methods: In this prospective study approved by the Institute Ethics Committee for Human Studies at Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER) the patients operated for glioma in 2014 and 2015 (n = 60) were included. Tumours were graded as per the World Health Organization (WHO) grading system. VEGF expression in various grades was analysed using immunohistochemistry. Results: Of the 60 patients included in this study, 15 were Grade II- (diffuse astrocytomas – 12; oligodendrogliomas- 3), 15 were Grade III-(anaplastic astrocytomas- 2; anaplastic oligodendrogliomas – 13) and 30 were Grade IV-glioblastomas. For VEGF antibody staining, two patients (3.33%) showed negative results and 58 patients (96%) showed positive results. VEGF positivity was 100% in Grade II and III, while it was 93.3% (28/30) in Grade IV tumours (p=0.012). Conclusion: The expression of VEGF was associated with the grade of tumour, which gradually increased from Grade II to Grade IV. We conclude that VEGF-regulated angiogenesis plays an important role in tumour progression of astrocytomas and oligodendrogliomas in the Indian population as observed worldwide.https://jcdr.net/articles/PDF/9331/24353_CE[Ra1]_F(GH)_PF1(PI_RK)_PFA(AK)_PF2(P_RB)_PF3(AG_OM).pdfangiogenesisastrocytic tumoursglial tumours |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ramya S Vokuda Bheemanathi Hanuman Srinivas Venkatesh S Madhugiri Surendra Kumar Verma |
spellingShingle |
Ramya S Vokuda Bheemanathi Hanuman Srinivas Venkatesh S Madhugiri Surendra Kumar Verma Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario Journal of Clinical and Diagnostic Research angiogenesis astrocytic tumours glial tumours |
author_facet |
Ramya S Vokuda Bheemanathi Hanuman Srinivas Venkatesh S Madhugiri Surendra Kumar Verma |
author_sort |
Ramya S Vokuda |
title |
Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario |
title_short |
Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario |
title_full |
Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario |
title_fullStr |
Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario |
title_full_unstemmed |
Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario |
title_sort |
vascular endothelial growth factor as an angiogenic marker in malignant astrocytoma and oligodendroglioma: an indian scenario |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2017-02-01 |
description |
Introduction: The role of Vascular Endothelial Growth Factor
(VEGF) in angiogenesis has been extensively studied in gliomas,
such as astrocytoma and oligodendrogliomas, worldwide.
However, there is limited information available with regard to
the Indian population.
Aim: To study, whether VEGF is expressed in the Indian
population in a pattern similar to that in other population.
Materials and Methods: In this prospective study approved by
the Institute Ethics Committee for Human Studies at Jawaharlal
Institute of Post Graduate Medical Education and Research
(JIPMER) the patients operated for glioma in 2014 and 2015
(n = 60) were included. Tumours were graded as per the World
Health Organization (WHO) grading system. VEGF expression in
various grades was analysed using immunohistochemistry.
Results: Of the 60 patients included in this study, 15 were
Grade II- (diffuse astrocytomas – 12; oligodendrogliomas- 3),
15 were Grade III-(anaplastic astrocytomas- 2; anaplastic
oligodendrogliomas – 13) and 30 were Grade IV-glioblastomas.
For VEGF antibody staining, two patients (3.33%) showed
negative results and 58 patients (96%) showed positive results.
VEGF positivity was 100% in Grade II and III, while it was 93.3%
(28/30) in Grade IV tumours (p=0.012).
Conclusion: The expression of VEGF was associated with
the grade of tumour, which gradually increased from Grade II
to Grade IV. We conclude that VEGF-regulated angiogenesis
plays an important role in tumour progression of astrocytomas
and oligodendrogliomas in the Indian population as observed
worldwide. |
topic |
angiogenesis astrocytic tumours glial tumours |
url |
https://jcdr.net/articles/PDF/9331/24353_CE[Ra1]_F(GH)_PF1(PI_RK)_PFA(AK)_PF2(P_RB)_PF3(AG_OM).pdf |
work_keys_str_mv |
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