New treatment approaches in melanoma: current research and clinical prospects

New treatment approaches in melanoma: current research and clinical prospects

Ipilimumab and vemurafenib have changed the clinical landscape in melanoma. Both drugs offer effective treatment for metastatic melanoma, but with limitations. Ipilimumab benefits only a minority of those treated, with no means to identify them prospectively. The efficacy of vemurafenib is tied to t...

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Main Authors: Milap G. Rughani, Avinash Gupta, Mark R. Middleton
Format: Article
Language:English
Published: SAGE Publishing 2013-01-01
Series:Therapeutic Advances in Medical Oncology
Online Access:https://doi.org/10.1177/1758834012463260
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spelling doaj-565f5b82a59746f49f992976ce1ef69f2020-11-25T03:17:17ZengSAGE PublishingTherapeutic Advances in Medical Oncology1758-83401758-83592013-01-01510.1177/1758834012463260New treatment approaches in melanoma: current research and clinical prospectsMilap G. RughaniAvinash GuptaMark R. MiddletonIpilimumab and vemurafenib have changed the clinical landscape in melanoma. Both drugs offer effective treatment for metastatic melanoma, but with limitations. Ipilimumab benefits only a minority of those treated, with no means to identify them prospectively. The efficacy of vemurafenib is tied to the presence of an activating mutation in BRAF, and so is more predictable. However, acquired resistance develops within months. As we understand these, and similar, agents better, the means to select patients for treatment, to increase the duration of response and to identify the best stage at which to intervene will lead to improved outcomes for patients. Several trials are already under way or being developed to build upon these exciting discoveries.https://doi.org/10.1177/1758834012463260
collection DOAJ
language English
format Article
sources DOAJ
author Milap G. Rughani
Avinash Gupta
Mark R. Middleton
spellingShingle Milap G. Rughani
Avinash Gupta
Mark R. Middleton
New treatment approaches in melanoma: current research and clinical prospects
Therapeutic Advances in Medical Oncology
author_facet Milap G. Rughani
Avinash Gupta
Mark R. Middleton
author_sort Milap G. Rughani
title New treatment approaches in melanoma: current research and clinical prospects
title_short New treatment approaches in melanoma: current research and clinical prospects
title_full New treatment approaches in melanoma: current research and clinical prospects
title_fullStr New treatment approaches in melanoma: current research and clinical prospects
title_full_unstemmed New treatment approaches in melanoma: current research and clinical prospects
title_sort new treatment approaches in melanoma: current research and clinical prospects
publisher SAGE Publishing
series Therapeutic Advances in Medical Oncology
issn 1758-8340
1758-8359
publishDate 2013-01-01
description Ipilimumab and vemurafenib have changed the clinical landscape in melanoma. Both drugs offer effective treatment for metastatic melanoma, but with limitations. Ipilimumab benefits only a minority of those treated, with no means to identify them prospectively. The efficacy of vemurafenib is tied to the presence of an activating mutation in BRAF, and so is more predictable. However, acquired resistance develops within months. As we understand these, and similar, agents better, the means to select patients for treatment, to increase the duration of response and to identify the best stage at which to intervene will lead to improved outcomes for patients. Several trials are already under way or being developed to build upon these exciting discoveries.
url https://doi.org/10.1177/1758834012463260
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AT avinashgupta newtreatmentapproachesinmelanomacurrentresearchandclinicalprospects
AT markrmiddleton newtreatmentapproachesinmelanomacurrentresearchandclinicalprospects
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