Elevated CO2 Levels Delay Skeletal Muscle Repair by Increasing Fatty Acid Oxidation

Elevated CO2 Levels Delay Skeletal Muscle Repair by Increasing Fatty Acid Oxidation

Muscle dysfunction often occurs in patients with chronic obstructive pulmonary diseases (COPD) and affects ventilatory and non-ventilatory skeletal muscles. We have previously reported that hypercapnia (elevated CO2 levels) causes muscle atrophy through the activation of the AMPKα2-FoxO3a-MuRF1 path...

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Bibliographic Details
Main Authors: Ermelinda Ceco, Diego Celli, Samuel Weinberg, Masahiko Shigemura, Lynn C. Welch, Lena Volpe, Navdeep S. Chandel, Ankit Bharat, Emilia Lecuona, Jacob I. Sznajder
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Physiology
Subjects:
hypercapnia
chronic obstructive pulmonary diseases
muscle differentiation
β-Oxidation
cardiotoxin
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.630910/full

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