The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins

The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins

The extracellular Contractile Injection System (eCIS) is a toxin-delivery particle that mediates interactions between bacteria and their invertebrate hosts. Here, the authors catalogue eCIS loci from 1,249 prokaryotic genomes, showing enrichment in non-pathogenic environmental microbes, and identify...

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Main Authors: Alexander Martin Geller, Inbal Pollin, David Zlotkin, Aleks Danov, Nimrod Nachmias, William B. Andreopoulos, Keren Shemesh, Asaf Levy
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23777-7
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spelling doaj-564af667027a4f3d80febcda2fb8b0602021-06-20T11:11:29ZengNature Publishing GroupNature Communications2041-17232021-06-0112111510.1038/s41467-021-23777-7The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxinsAlexander Martin Geller0Inbal Pollin1David Zlotkin2Aleks Danov3Nimrod Nachmias4William B. Andreopoulos5Keren Shemesh6Asaf Levy7Department of Plant Pathology and Microbiology, the Robert H. Smith Faculty of Food and Environment, the Hebrew University of JerusalemDepartment of Plant Pathology and Microbiology, the Robert H. Smith Faculty of Food and Environment, the Hebrew University of JerusalemDepartment of Plant Pathology and Microbiology, the Robert H. Smith Faculty of Food and Environment, the Hebrew University of JerusalemDepartment of Plant Pathology and Microbiology, the Robert H. Smith Faculty of Food and Environment, the Hebrew University of JerusalemDepartment of Plant Pathology and Microbiology, the Robert H. Smith Faculty of Food and Environment, the Hebrew University of JerusalemDepartment of Computer Science, San Jose State UniversityDepartment of Plant Pathology and Microbiology, the Robert H. Smith Faculty of Food and Environment, the Hebrew University of JerusalemDepartment of Plant Pathology and Microbiology, the Robert H. Smith Faculty of Food and Environment, the Hebrew University of JerusalemThe extracellular Contractile Injection System (eCIS) is a toxin-delivery particle that mediates interactions between bacteria and their invertebrate hosts. Here, the authors catalogue eCIS loci from 1,249 prokaryotic genomes, showing enrichment in non-pathogenic environmental microbes, and identifying eCIS-associated toxins that inhibit the growth of bacteria and/or yeast.https://doi.org/10.1038/s41467-021-23777-7
collection DOAJ
language English
format Article
sources DOAJ
author Alexander Martin Geller
Inbal Pollin
David Zlotkin
Aleks Danov
Nimrod Nachmias
William B. Andreopoulos
Keren Shemesh
Asaf Levy
spellingShingle Alexander Martin Geller
Inbal Pollin
David Zlotkin
Aleks Danov
Nimrod Nachmias
William B. Andreopoulos
Keren Shemesh
Asaf Levy
The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins
Nature Communications
author_facet Alexander Martin Geller
Inbal Pollin
David Zlotkin
Aleks Danov
Nimrod Nachmias
William B. Andreopoulos
Keren Shemesh
Asaf Levy
author_sort Alexander Martin Geller
title The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins
title_short The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins
title_full The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins
title_fullStr The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins
title_full_unstemmed The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins
title_sort extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description The extracellular Contractile Injection System (eCIS) is a toxin-delivery particle that mediates interactions between bacteria and their invertebrate hosts. Here, the authors catalogue eCIS loci from 1,249 prokaryotic genomes, showing enrichment in non-pathogenic environmental microbes, and identifying eCIS-associated toxins that inhibit the growth of bacteria and/or yeast.
url https://doi.org/10.1038/s41467-021-23777-7
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