Spontaneous neurotransmission signals through store-driven Ca2+ transients to maintain synaptic homeostasis

Spontaneous neurotransmission signals through store-driven Ca2+ transients to maintain synaptic homeostasis

Spontaneous glutamate release-driven NMDA receptor activity exerts a strong influence on synaptic homeostasis. However, the properties of Ca2+ signals that mediate this effect remain unclear. Here, using hippocampal neurons labeled with the fluorescent Ca2+ probes Fluo-4 or GCAMP5, we visualized act...

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Bibliographic Details
Main Authors: Austin L Reese, Ege T Kavalali
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
spontaneous neurotransmitter release
NMDA receptor signaling
Ca2+ induced Ca2+ release
homeostatic plasticity
Online Access:https://elifesciences.org/articles/09262

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