Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages

Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages

Abstract Exosomes are extracellular vesicles characterized by their size, source, release mechanism and contents. MicroRNAs (miRNAs) are single stranded non-coding RNAs transcribed from DNA. Exosomes and miRNAs are widespread in eukaryotic cells, especially in mesenchymal stem cells (MSCs). MSCs are...

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Main Authors: Kasra Asgarpour, Zahra Shojaei, Fatemeh Amiri, Jafar Ai, Maryam Mahjoubin-Tehran, Faezeh Ghasemi, Reza ArefNezhad, Michael R. Hamblin, Hamed Mirzaei
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Cell Communication and Signaling
Subjects:
Mesenchymal stem cells
Exosomes
MicroRNA
Online Access:http://link.springer.com/article/10.1186/s12964-020-00650-6
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spelling doaj-5646edbe30bf4e2b8c66f054cee48bd92020-11-25T03:05:32ZengBMCCell Communication and Signaling1478-811X2020-09-0118111610.1186/s12964-020-00650-6Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messagesKasra Asgarpour0Zahra Shojaei1Fatemeh Amiri2Jafar Ai3Maryam Mahjoubin-Tehran4Faezeh Ghasemi5Reza ArefNezhad6Michael R. Hamblin7Hamed Mirzaei8Department of Medicine, University of Western OntarioSchool of Medicine, Shahid Beheshti University of Medical SciencesSchool of Allied Medical Sciences, Hamadan University of Medical SciencesDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine (SATM), Tehran University of Medical Sciences (TUMS)Student Research Committee, Mashhad University of Medical SciencesBlood Transfusion Research Center, High Institute for Research and Education in Transfusion MedicineDepartment of Anatomy, School of Medicine, Shiraz University of Medical SciencesWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical SchoolResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical SciencesAbstract Exosomes are extracellular vesicles characterized by their size, source, release mechanism and contents. MicroRNAs (miRNAs) are single stranded non-coding RNAs transcribed from DNA. Exosomes and miRNAs are widespread in eukaryotic cells, especially in mesenchymal stem cells (MSCs). MSCs are used for tissue regeneration, and also exert paracrine, anti-inflammatory and immunomodulatory effects. However, the use of MSCs is controversial, especially in the presence or after the remission of a tumor, due to their secretion of growth factors and their migration ability. Instead of intact MSCs, MSC-derived compartments or substances could be used as practical tools for diagnosis, follow up, management and monitoring of diseases. Herein, we discuss some aspects of exosomal miRNAs derived from MSCs in the progression, diagnosis and treatment of various diseases. Video Abstracthttp://link.springer.com/article/10.1186/s12964-020-00650-6Mesenchymal stem cellsExosomesMicroRNA
collection DOAJ
language English
format Article
sources DOAJ
author Kasra Asgarpour
Zahra Shojaei
Fatemeh Amiri
Jafar Ai
Maryam Mahjoubin-Tehran
Faezeh Ghasemi
Reza ArefNezhad
Michael R. Hamblin
Hamed Mirzaei
spellingShingle Kasra Asgarpour
Zahra Shojaei
Fatemeh Amiri
Jafar Ai
Maryam Mahjoubin-Tehran
Faezeh Ghasemi
Reza ArefNezhad
Michael R. Hamblin
Hamed Mirzaei
Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages
Cell Communication and Signaling
Mesenchymal stem cells
Exosomes
MicroRNA
author_facet Kasra Asgarpour
Zahra Shojaei
Fatemeh Amiri
Jafar Ai
Maryam Mahjoubin-Tehran
Faezeh Ghasemi
Reza ArefNezhad
Michael R. Hamblin
Hamed Mirzaei
author_sort Kasra Asgarpour
title Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages
title_short Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages
title_full Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages
title_fullStr Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages
title_full_unstemmed Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages
title_sort exosomal micrornas derived from mesenchymal stem cells: cell-to-cell messages
publisher BMC
series Cell Communication and Signaling
issn 1478-811X
publishDate 2020-09-01
description Abstract Exosomes are extracellular vesicles characterized by their size, source, release mechanism and contents. MicroRNAs (miRNAs) are single stranded non-coding RNAs transcribed from DNA. Exosomes and miRNAs are widespread in eukaryotic cells, especially in mesenchymal stem cells (MSCs). MSCs are used for tissue regeneration, and also exert paracrine, anti-inflammatory and immunomodulatory effects. However, the use of MSCs is controversial, especially in the presence or after the remission of a tumor, due to their secretion of growth factors and their migration ability. Instead of intact MSCs, MSC-derived compartments or substances could be used as practical tools for diagnosis, follow up, management and monitoring of diseases. Herein, we discuss some aspects of exosomal miRNAs derived from MSCs in the progression, diagnosis and treatment of various diseases. Video Abstract
topic Mesenchymal stem cells
Exosomes
MicroRNA
url http://link.springer.com/article/10.1186/s12964-020-00650-6
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