Cell foundry with high product specificity and catalytic activity for 21-deoxycortisol biotransformation

Cell foundry with high product specificity and catalytic activity for 21-deoxycortisol biotransformation

Abstract Background 21-deoxycortisol (21-DF) is the key intermediate to manufacture pharmaceutical glucocorticoids. Recently, a Japan patent has realized 21-DF production via biotransformation of 17-hydroxyprogesterone (17-OHP) by purified steroid 11β-hydroxylase CYP11B1. Due to the less costs on en...

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Bibliographic Details
Main Authors: Shuting Xiong, Ying Wang, Mingdong Yao, Hong Liu, Xiao Zhou, Wenhai Xiao, Yingjin Yuan
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Microbial Cell Factories
Subjects:
Synthetic biology
Whole-cell biocatalysis
Product specificity
Catalytic activity
21-Deoxycortisol
CYP11B1
Online Access:http://link.springer.com/article/10.1186/s12934-017-0720-y

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http://link.springer.com/article/10.1186/s12934-017-0720-y

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