Mechanism of membrane-curvature generation by ER-tubule shaping proteins

Mechanism of membrane-curvature generation by ER-tubule shaping proteins

The endoplasmic reticulum network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs, but how they introduce curvature is poorly understood. Here authors show that REEPs form homodimers and use their amphipathic helix and trans-membrane segments...

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Bibliographic Details
Main Authors: Ning Wang, Lindsay D. Clark, Yuan Gao, Michael M. Kozlov, Tom Shemesh, Tom A. Rapoport
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20625-y

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