Mechanism of membrane-curvature generation by ER-tubule shaping proteins

Mechanism of membrane-curvature generation by ER-tubule shaping proteins

The endoplasmic reticulum network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs, but how they introduce curvature is poorly understood. Here authors show that REEPs form homodimers and use their amphipathic helix and trans-membrane segments...

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Main Authors: Ning Wang, Lindsay D. Clark, Yuan Gao, Michael M. Kozlov, Tom Shemesh, Tom A. Rapoport
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20625-y
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spelling doaj-56438c7966b446978619a8f0309f56732021-01-31T12:20:00ZengNature Publishing GroupNature Communications2041-17232021-01-0112111510.1038/s41467-020-20625-yMechanism of membrane-curvature generation by ER-tubule shaping proteinsNing Wang0Lindsay D. Clark1Yuan Gao2Michael M. Kozlov3Tom Shemesh4Tom A. Rapoport5Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical SchoolHoward Hughes Medical Institute and Department of Cell Biology, Harvard Medical SchoolHoward Hughes Medical Institute and Department of Cell Biology, Harvard Medical SchoolDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv UniversityFaculty of Biology, Technion-Israel Institute of TechnologyHoward Hughes Medical Institute and Department of Cell Biology, Harvard Medical SchoolThe endoplasmic reticulum network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs, but how they introduce curvature is poorly understood. Here authors show that REEPs form homodimers and use their amphipathic helix and trans-membrane segments to introduce high membrane curvature that can even lead to the formation of lipoprotein particles.https://doi.org/10.1038/s41467-020-20625-y
collection DOAJ
language English
format Article
sources DOAJ
author Ning Wang
Lindsay D. Clark
Yuan Gao
Michael M. Kozlov
Tom Shemesh
Tom A. Rapoport
spellingShingle Ning Wang
Lindsay D. Clark
Yuan Gao
Michael M. Kozlov
Tom Shemesh
Tom A. Rapoport
Mechanism of membrane-curvature generation by ER-tubule shaping proteins
Nature Communications
author_facet Ning Wang
Lindsay D. Clark
Yuan Gao
Michael M. Kozlov
Tom Shemesh
Tom A. Rapoport
author_sort Ning Wang
title Mechanism of membrane-curvature generation by ER-tubule shaping proteins
title_short Mechanism of membrane-curvature generation by ER-tubule shaping proteins
title_full Mechanism of membrane-curvature generation by ER-tubule shaping proteins
title_fullStr Mechanism of membrane-curvature generation by ER-tubule shaping proteins
title_full_unstemmed Mechanism of membrane-curvature generation by ER-tubule shaping proteins
title_sort mechanism of membrane-curvature generation by er-tubule shaping proteins
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-01-01
description The endoplasmic reticulum network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs, but how they introduce curvature is poorly understood. Here authors show that REEPs form homodimers and use their amphipathic helix and trans-membrane segments to introduce high membrane curvature that can even lead to the formation of lipoprotein particles.
url https://doi.org/10.1038/s41467-020-20625-y
work_keys_str_mv AT ningwang mechanismofmembranecurvaturegenerationbyertubuleshapingproteins
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AT yuangao mechanismofmembranecurvaturegenerationbyertubuleshapingproteins
AT michaelmkozlov mechanismofmembranecurvaturegenerationbyertubuleshapingproteins
AT tomshemesh mechanismofmembranecurvaturegenerationbyertubuleshapingproteins
AT tomarapoport mechanismofmembranecurvaturegenerationbyertubuleshapingproteins
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