Immunogenicity and Protective Efficacy of Influenza A DNA Vaccines Encoding Artificial Antigens Based on Conservative Hemagglutinin Stem Region and M2 Protein in Mice

Immunogenicity and Protective Efficacy of Influenza A DNA Vaccines Encoding Artificial Antigens Based on Conservative Hemagglutinin Stem Region and M2 Protein in Mice

Background: Development of a universal vaccine capable to induce antibody responses against a broad range of influenza virus strains attracts growing attention. Hemagglutinin stem and the exposed fragment of influenza virus M2 protein are promising targets for induction of cross-protective humoral a...

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Bibliographic Details
Main Authors: Sergei Bazhan, Denis Antonets, Ekaterina Starostina, Tatyana Ilyicheva, Olga Kaplina, Vasiliy Marchenko, Alexander Durymanov, Svetlana Oreshkova, Larisa Karpenko
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Vaccines
Subjects:
influenza virus
DNA-vaccine constructs
artificial polyepitope T-cell immunogens
hemagglutinin stem region
M2 protein
cross-protective influenza immunity
Online Access:https://www.mdpi.com/2076-393X/8/3/448

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