PACAP-38 and PACAP(6–38) Degranulate Rat Meningeal Mast Cells via the Orphan MrgB3-Receptor

PACAP-38 and PACAP(6–38) Degranulate Rat Meningeal Mast Cells via the Orphan MrgB3-Receptor

Infusion of pituitary adenylate cyclase activating peptide-38 (PACAP-38) provokes migraine attacks in migraineurs and headache in non-migraineurs. Adverse events like long-lasting flushing and heat sensation can be terminated with oral antihistamine treatment, indicating the involvement of mast cell...

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Bibliographic Details
Main Authors: Sara Hougaard Pedersen, Sanne Hage la Cour, Kirstine Calloe, Frank Hauser, Jes Olesen, Dan Arne Klaerke, Inger Jansen-Olesen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
migraine
pituitary adenylate cyclase activating peptide
dura mater
Xenopus laevis oocytes
mast cell
Mas-related G-protein coupled receptor member B3
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00114/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00114/full

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