Brain tumor-initiating cells export tenascin-C associated with exosomes to suppress T cell activity

Brain tumor-initiating cells export tenascin-C associated with exosomes to suppress T cell activity

The dismal prognosis of glioblastoma is attributed in part to the existence of stem-like brain tumor-initiating cells (BTICs) that are highly radio- and chemo-resistant. New approaches such as therapies that reprogram compromised immune cells against BTICs are needed. Effective immunotherapies in gl...

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Bibliographic Details
Main Authors: Reza Mirzaei, Susobhan Sarkar, Lauren Dzikowski, Khalil S. Rawji, Lubaba Khan, Andreas Faissner, Pinaki Bose, V. Wee Yong
Format: Article
Language:English
Published: Taylor & Francis Group 2018-10-01
Series:OncoImmunology
Subjects:
cancer stem cells
glioma
adaptive immunity
extracellular matrix
exosome
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1478647

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