Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa

Selection on alleles contributing to human evolution is not well understood. Here, the authors investigate positive selection on skin barrier adaptation, identifying a selective sweep on involucrin alleles associated with migration out of Africa, and confirming enhancer regulatory effects with funct...

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Main Authors:	Mary Elizabeth Mathyer, Erin A. Brettmann, Alina D. Schmidt, Zane A. Goodwin, Inez Y. Oh, Ashley M. Quiggle, Eric Tycksen, Natasha Ramakrishnan, Scot J. Matkovich, Emma Guttman-Yassky, John R. Edwards, Cristina de Guzman Strong
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-22821-w

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spelling	doaj-562d1faba6444cc8a292faa17015f06a2021-05-09T11:12:35ZengNature Publishing GroupNature Communications2041-17232021-05-0112111210.1038/s41467-021-22821-wSelective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of AfricaMary Elizabeth Mathyer0Erin A. Brettmann1Alina D. Schmidt2Zane A. Goodwin3Inez Y. Oh4Ashley M. Quiggle5Eric Tycksen6Natasha Ramakrishnan7Scot J. Matkovich8Emma Guttman-Yassky9John R. Edwards10Cristina de Guzman Strong11Division of Dermatology, Department of Medicine, Washington University in St. Louis School of MedicineDivision of Dermatology, Department of Medicine, Washington University in St. Louis School of MedicineDivision of Dermatology, Department of Medicine, Washington University in St. Louis School of MedicineDivision of Dermatology, Department of Medicine, Washington University in St. Louis School of MedicineDivision of Dermatology, Department of Medicine, Washington University in St. Louis School of MedicineDivision of Dermatology, Department of Medicine, Washington University in St. Louis School of MedicineMcDonnell Genome Institute, Washington University in St. Louis School of MedicineDivision of Dermatology, Department of Medicine, Washington University in St. Louis School of MedicineCenter for Pharmacogenomics, Department of Medicine, Washington University in St. Louis School of MedicineDepartment of Dermatology, Icahn School of Medicine at Mt. SinaiCenter for Pharmacogenomics, Department of Medicine, Washington University in St. Louis School of MedicineDivision of Dermatology, Department of Medicine, Washington University in St. Louis School of MedicineSelection on alleles contributing to human evolution is not well understood. Here, the authors investigate positive selection on skin barrier adaptation, identifying a selective sweep on involucrin alleles associated with migration out of Africa, and confirming enhancer regulatory effects with functional assays.https://doi.org/10.1038/s41467-021-22821-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mary Elizabeth Mathyer Erin A. Brettmann Alina D. Schmidt Zane A. Goodwin Inez Y. Oh Ashley M. Quiggle Eric Tycksen Natasha Ramakrishnan Scot J. Matkovich Emma Guttman-Yassky John R. Edwards Cristina de Guzman Strong
spellingShingle	Mary Elizabeth Mathyer Erin A. Brettmann Alina D. Schmidt Zane A. Goodwin Inez Y. Oh Ashley M. Quiggle Eric Tycksen Natasha Ramakrishnan Scot J. Matkovich Emma Guttman-Yassky John R. Edwards Cristina de Guzman Strong Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa Nature Communications
author_facet	Mary Elizabeth Mathyer Erin A. Brettmann Alina D. Schmidt Zane A. Goodwin Inez Y. Oh Ashley M. Quiggle Eric Tycksen Natasha Ramakrishnan Scot J. Matkovich Emma Guttman-Yassky John R. Edwards Cristina de Guzman Strong
author_sort	Mary Elizabeth Mathyer
title	Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa
title_short	Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa
title_full	Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa
title_fullStr	Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa
title_full_unstemmed	Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa
title_sort	selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of africa
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-05-01
description	Selection on alleles contributing to human evolution is not well understood. Here, the authors investigate positive selection on skin barrier adaptation, identifying a selective sweep on involucrin alleles associated with migration out of Africa, and confirming enhancer regulatory effects with functional assays.
url	https://doi.org/10.1038/s41467-021-22821-w
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Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa

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