Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa
Selection on alleles contributing to human evolution is not well understood. Here, the authors investigate positive selection on skin barrier adaptation, identifying a selective sweep on involucrin alleles associated with migration out of Africa, and confirming enhancer regulatory effects with funct...
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Bibliographic Details
| Main Authors: |
Mary Elizabeth Mathyer,
Erin A. Brettmann,
Alina D. Schmidt,
Zane A. Goodwin,
Inez Y. Oh,
Ashley M. Quiggle,
Eric Tycksen,
Natasha Ramakrishnan,
Scot J. Matkovich,
Emma Guttman-Yassky,
John R. Edwards,
Cristina de Guzman Strong |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-22821-w
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