The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa

The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa

T follicular helper cells (Tfh) are crucial for the initiation and maintenance of germinal center (GC) reactions and high affinity, isotype-switched antibody responses. In this study, we demonstrate that direct TGF-β signaling to CD4 T cells is important for the formation of influenza-specific Tfh c...

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Bibliographic Details
Main Authors: Heather D Marshall, John P Ray, Brian J Laidlaw, Nianzhi Zhang, Dipika Gawande, Matthew M Staron, Joe Craft, Susan M Kaech
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-01-01
Series:eLife
Subjects:
T follicular helper cell
viral infection
antibody
TGF-beta
cytokine
Online Access:https://elifesciences.org/articles/04851

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