The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor, and reveal a function for praziquantel as a regu...

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Main Authors:	John D. Chan, Pauline M. Cupit, Gihan S. Gunaratne, John D. McCorvy, Yang Yang, Kristen Stoltz, Thomas R. Webb, Peter I. Dosa, Bryan L. Roth, Ruben Abagyan, Charles Cunningham, Jonathan S. Marchant
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02084-0

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spelling	doaj-562739954b0b4cf0ad3e903c389b980c2021-05-11T07:42:44ZengNature Publishing GroupNature Communications2041-17232017-12-01811710.1038/s41467-017-02084-0The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligandJohn D. Chan0Pauline M. Cupit1Gihan S. Gunaratne2John D. McCorvy3Yang Yang4Kristen Stoltz5Thomas R. Webb6Peter I. Dosa7Bryan L. Roth8Ruben Abagyan9Charles Cunningham10Jonathan S. Marchant11Department of Pharmacology, University of MinnesotaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San DiegoDepartment of Pharmacology, University of MinnesotaDepartment of Pharmacology, University of North Carolina at Chapel HillDepartment of Pharmacology, University of MinnesotaInstitute for Therapeutics Discovery and Development, University of MinnesotaDivision of Biosciences, SRI InternationalInstitute for Therapeutics Discovery and Development, University of MinnesotaDepartment of Pharmacology, University of North Carolina at Chapel HillSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San DiegoDepartment of Biology, University of New MexicoDepartment of Pharmacology, University of MinnesotaSchistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor, and reveal a function for praziquantel as a regulator of vascular tone in treated hosts.https://doi.org/10.1038/s41467-017-02084-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	John D. Chan Pauline M. Cupit Gihan S. Gunaratne John D. McCorvy Yang Yang Kristen Stoltz Thomas R. Webb Peter I. Dosa Bryan L. Roth Ruben Abagyan Charles Cunningham Jonathan S. Marchant
spellingShingle	John D. Chan Pauline M. Cupit Gihan S. Gunaratne John D. McCorvy Yang Yang Kristen Stoltz Thomas R. Webb Peter I. Dosa Bryan L. Roth Ruben Abagyan Charles Cunningham Jonathan S. Marchant The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand Nature Communications
author_facet	John D. Chan Pauline M. Cupit Gihan S. Gunaratne John D. McCorvy Yang Yang Kristen Stoltz Thomas R. Webb Peter I. Dosa Bryan L. Roth Ruben Abagyan Charles Cunningham Jonathan S. Marchant
author_sort	John D. Chan
title	The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
title_short	The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
title_full	The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
title_fullStr	The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
title_full_unstemmed	The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
title_sort	anthelmintic praziquantel is a human serotoninergic g-protein-coupled receptor ligand
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-12-01
description	Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor, and reveal a function for praziquantel as a regulator of vascular tone in treated hosts.
url	https://doi.org/10.1038/s41467-017-02084-0
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The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

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