Roles of Stem Cells in the Treatment of Alzheimer’s Disease

• Main Authors: Yasaman Ebrahimikia, Shahram Darabi, Farzad Rajaei
• Format: Article
• Language: fas
• Published: Shahid Sadoughi University of Medical Sciences 2020-06-01
• Series: Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
• Subjects: stem cell; alzheimer's disease; amyloid-β
• Online Access: http://jssu.ssu.ac.ir/article-1-4638-en.html

Introduction: Alzheimer disease (AD), known to be a leading cause of dementia that causes heavy social and financial burdens worldwide, characterized by progressive loss of neurons and synaptic connectivity after depositions of amyloid-β (Aβ) protein.AD manifests as an impaired ability to comprehend or use words, poor coordination and gait, and impaired executive functions in the realms of planning, ordering and making judgments. Generally, classification of AD includes familial and sporadic AD. Current therapies for AD patients can only alleviate symptoms, but cannot deter the neural degeneration, thus providing no long-term recovery. Stem cells are undifferentiated cells that have a potential to produce many different cell types in the body. A vast amount of data indicates the potential of stem cell therapy for various neurological diseases. Several studies revealed that neurons and glial cells have successfully been differentiated from various stem cells. Thus, in this article, we review the treatment of Alzheimer disease by various types of stem cells.