Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss.

Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss.

Recurrent pregnancy loss (RPL), defined as 3 or more consecutive miscarriages, is widely attributed either to repeated chromosomal instability in the conceptus or to uterine factors that are poorly defined. We tested the hypothesis that abnormal cyclic differentiation of endometrial stromal cells (E...

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Main Authors: Madhuri Salker, Gijs Teklenburg, Mariam Molokhia, Stuart Lavery, Geoffrey Trew, Tepchongchit Aojanepong, Helen J Mardon, Amali U Lokugamage, Raj Rai, Christian Landles, Bernard A J Roelen, Siobhan Quenby, Ewart W Kuijk, Annemieke Kavelaars, Cobi J Heijnen, Lesley Regan, Nick S Macklon, Jan J Brosens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2858209?pdf=render

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