Tabersonine ameliorates osteoblast apoptosis in rats with dexamethasone-induced osteoporosis by regulating the Nrf2/ROS/Bax signalling pathway

Tabersonine ameliorates osteoblast apoptosis in rats with dexamethasone-induced osteoporosis by regulating the Nrf2/ROS/Bax signalling pathway

Abstract We explored how tabersonine (Tab) protected against dexamethasone (Dex)-induced osteoporosis. Osteoblasts were treated with Dex (100 µM) with or without Table (5 or 10 µM). We measured cell viability, alkaline phosphatase (ALP) activity, and mitochondrial superoxide and reactive oxygen spec...

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Bibliographic Details
Main Authors: Xi Sun, Lijun Gan, Nan Li, Shuyi Sun, Na Li
Format: Article
Language:English
Published: SpringerOpen 2020-09-01
Series:AMB Express
Subjects:
Tabersonine
Dexamethasone
Osteoporosis
Osteoblast
Inflammation
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s13568-020-01098-0

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