Long-term heavy ketamine use is associated with spatial memory impairment and altered hippocampal activation

Long-term heavy ketamine use is associated with spatial memory impairment and altered hippocampal activation

Ketamine, a non-competitive N-methyl-D-aspartate receptor antagonist, is rising in popularity as a drug of abuse. Preliminary evidence suggests that chronic, heavy ketamine use may have profound effects on spatial memory but the mechanism of these deficits is as yet unclear. This study aimed to exam...

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Bibliographic Details
Main Authors: Celia J A Morgan, Chris eDodds, Hannah eFurby, Fiona ePepper, Johnson eFam, Tom eFreeman, Emer eHughes, Christian eDoeller, John eKing, James eStone, Oliver eHowes
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Psychiatry
Subjects:
Hippocampus
Ketamine
Memory
spatial memory
Drug abuse
NMDA receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00149/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00149/full

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