| Summary: | Introduction: Sepsis is a group of symptoms caused by infection, characterized by
organ dysfunction due to compromised hosts response to infection hence may lead
to a life-threatening condition. One of the treatments for sepsis stated in one hour-
bundle is the administration of broad-spectrum antibiotics before the culture results
obtained. Improper use of antibiotics may lead to antibiotic resistance. The purpose
of this study was to describe the microbes pattern and their sensitivity to antibiotics
in patients with sepsis at Muhammad Hoesin Hospital, Palembang, to contribute to
a useful treatment guideline and to provide a reference for further research.
Methods: This study was a descriptive observational study with a cross-sectional
design using medical record of patients diagnosed with sepsis whose blood culture
results were positive. This study was conducted at Muhammad Hoesin Hospital,
Palembang, from January 2017 to December 2018. The data was processed and
analyzed by univariate analysis using the SPSS 21.0 computer program. Results:
The study subjects were predominantly children with Gram-positive bacteria
(24.6%) as the most common cause. The most common bacteria observed were
Staphylococcus epidermidis (35.7%), Staphylococcus aureus (27.3%), Staphylococcus
haemolyticus (24%), and Staphylococcus hominis (21.4%). Linezolid (100%),
nitrofurantoin (100%), and quinupristin/dalfopristin (100%) were found to be
sensitive to gram-positive bacteria. Conclusion: Gram-positive bacteria were the
most common cause of sepsis in Muhammad Hoesin Hospital, Palembang. The
bacteria were sensitive to linezolid, nitrofurantoin, and quinupristin/ dalfopristin.
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