Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma

In recent years, advances in drug therapy for head and neck squamous cell carcinoma (HNSCC) have progressed rapidly. In addition to cytotoxic anti-cancer agents such as platinum-based drug (cisplatin and carboplatin) and taxane-based drugs (docetaxel and paclitaxel), epidermal growth factor receptor...

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Main Authors:	Naoya Kitamura, Shinya Sento, Yasumasa Yoshizawa, Eri Sasabe, Yasusei Kudo, Tetsuya Yamamoto
Format:	Article
Language:	English
Published:	MDPI AG 2021-12-01
Series:	International Journal of Molecular Sciences
Subjects:	head and neck squamous cell carcinoma molecular targeted therapy cetuximab immune checkpoint inhibitor multi-oncogene panel test photoimmunotherapy
Online Access:	https://www.mdpi.com/1422-0067/22/1/240

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spelling	doaj-55fe6612f8614031b3aeab508bd4d5e02020-12-30T00:00:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-012224024010.3390/ijms22010240Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell CarcinomaNaoya Kitamura0Shinya Sento1Yasumasa Yoshizawa2Eri Sasabe3Yasusei Kudo4Tetsuya Yamamoto5Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nankoku, Kochi 783-8505, JapanDepartment of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nankoku, Kochi 783-8505, JapanDepartment of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nankoku, Kochi 783-8505, JapanDepartment of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nankoku, Kochi 783-8505, JapanDepartment of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto, Tokushima 770-8504, JapanDepartment of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nankoku, Kochi 783-8505, JapanIn recent years, advances in drug therapy for head and neck squamous cell carcinoma (HNSCC) have progressed rapidly. In addition to cytotoxic anti-cancer agents such as platinum-based drug (cisplatin and carboplatin) and taxane-based drugs (docetaxel and paclitaxel), epidermal growth factor receptor-tyrosine kinase inhibitors (cetuximab) and immune checkpoint inhibitors such as anti-programmed cell death-1 (PD-1) antibodies (nivolumab and pembrolizumab) have come to be used. The importance of anti-cancer drug therapy is increasing year by year. Therefore, we summarize clinical trials of molecular targeted therapy and biomarkers in HNSCC from previous studies. Here we show the current trends and future prospects of molecular targeted therapy in HNSCC.https://www.mdpi.com/1422-0067/22/1/240head and neck squamous cell carcinomamolecular targeted therapycetuximabimmune checkpoint inhibitormulti-oncogene panel testphotoimmunotherapy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Naoya Kitamura Shinya Sento Yasumasa Yoshizawa Eri Sasabe Yasusei Kudo Tetsuya Yamamoto
spellingShingle	Naoya Kitamura Shinya Sento Yasumasa Yoshizawa Eri Sasabe Yasusei Kudo Tetsuya Yamamoto Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma International Journal of Molecular Sciences head and neck squamous cell carcinoma molecular targeted therapy cetuximab immune checkpoint inhibitor multi-oncogene panel test photoimmunotherapy
author_facet	Naoya Kitamura Shinya Sento Yasumasa Yoshizawa Eri Sasabe Yasusei Kudo Tetsuya Yamamoto
author_sort	Naoya Kitamura
title	Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma
title_short	Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma
title_full	Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma
title_fullStr	Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed	Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma
title_sort	current trends and future prospects of molecular targeted therapy in head and neck squamous cell carcinoma
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1661-6596 1422-0067
publishDate	2021-12-01
description	In recent years, advances in drug therapy for head and neck squamous cell carcinoma (HNSCC) have progressed rapidly. In addition to cytotoxic anti-cancer agents such as platinum-based drug (cisplatin and carboplatin) and taxane-based drugs (docetaxel and paclitaxel), epidermal growth factor receptor-tyrosine kinase inhibitors (cetuximab) and immune checkpoint inhibitors such as anti-programmed cell death-1 (PD-1) antibodies (nivolumab and pembrolizumab) have come to be used. The importance of anti-cancer drug therapy is increasing year by year. Therefore, we summarize clinical trials of molecular targeted therapy and biomarkers in HNSCC from previous studies. Here we show the current trends and future prospects of molecular targeted therapy in HNSCC.
topic	head and neck squamous cell carcinoma molecular targeted therapy cetuximab immune checkpoint inhibitor multi-oncogene panel test photoimmunotherapy
url	https://www.mdpi.com/1422-0067/22/1/240
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Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma

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