The Combined Use of Melatonin and an Indoleamine 2,3-Dioxygenase-1 Inhibitor Enhances Vaccine-Induced Protective Cellular Immunity to HPV16-Associated Tumors

The Combined Use of Melatonin and an Indoleamine 2,3-Dioxygenase-1 Inhibitor Enhances Vaccine-Induced Protective Cellular Immunity to HPV16-Associated Tumors

Immunotherapy has become an important ally in the fight against distinct types of cancer. However, the metabolic plasticity of the tumor environment frequently influences the efficacy of therapeutic procedures, including those based on immunological tools. In this scenario, immunometabolic adjuvants...

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Bibliographic Details
Main Authors: Ana C. R. Moreno, Bruna F. M. M. Porchia, Roberta L. Pagni, Patrícia da Cruz Souza, Rafael Pegoraro, Karine B. Rodrigues, Tácita B. Barros, Luana R. de Melo Moraes Aps, Eliseu F. de Araújo, Vera L. G. Calich, Luís C. de Souza Ferreira
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
melatonin
1-methyl-tryptophan
indoleamine 2
3 dioxygenase
human papillomavirus
cancer immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01914/full

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