The influence of the gut microbiome on BCG-induced trained immunity

The influence of the gut microbiome on BCG-induced trained immunity

Abstract Background The bacillus Calmette-Guérin (BCG) vaccine protects against tuberculosis and heterologous infections but elicits high inter-individual variation in specific and nonspecific, or trained, immune responses. While the gut microbiome is increasingly recognized as an important modulato...

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Bibliographic Details
Main Authors: Martin Stražar, Vera P. Mourits, Valerie A. C. M. Koeken, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Leo A. B. Joosten, Reinout van Crevel, Hera Vlamakis, Mihai G. Netea, Ramnik J. Xavier
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Genome Biology
Subjects:
Nonspecific immune responses
Trained immunity
BCG
Microbiome
Phenylalanine metabolism
Roseburia
Online Access:https://doi.org/10.1186/s13059-021-02482-0

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