THK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report

THK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report

Abstract Background THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucip...

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Bibliographic Details
Main Authors: Hee Jin Kim, Hanna Cho, Seongbeom Park, Hyemin Jang, Young Hoon Ryu, Jae Yong Choi, Seung Hwan Moon, Seung Jun Oh, Minyoung Oh, Duk L. Na, Chul Hyoung Lyoo, Eun-Joo Kim, William W. Seeley, Jae Seung Kim, Kyung Chan Choi, Sang Won Seo
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Neurology
Subjects:
THK5351 PET
Flortaucipir PET
Monoamine oxidase B
Creutzfeldt-Jakob disease
Online Access:http://link.springer.com/article/10.1186/s12883-019-1434-z

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